Hydrochloric Acid → 4-bromo-3-(trifluoromethyl)aniline HCl salt

HRID 491086

反応式

HRID 491086 の反応式
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[ClH:13]>CCOCC>[ClH:13].[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 678524-Bromo-3-(trifluoromethyl)aniline

生成物 1

HCID 667457074-bromo-3-(trifluoromethyl)aniline HCl salt収率 98%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 4-bromo-3-(trifluoromethyl)aniline (64 g, 267 mmol) in Et2O (500 mL) was added an HCl solution (1 M in Et2O; 300 mL) dropwise and the resulting mixture was stirred at room temp. for 16 h. The resulting pink-white precipitate was removed by filtration and washed with Et2O (50 mL) and to afford 4-bromo-3-(trifluoromethyl)aniline HCl salt (73 g, 98%).

後処理

  1. customThe resulting pink-white precipitate was removed by filtration
  2. washwashed with Et2O (50 mL)

出典と根拠

ORDレコード
ord-6ce5a368866f4d38a33d544009dbcb7d
出典データセット
uspto-grants-2009_05
特許番号
US07528255B2

関連ノート

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