Bromine → 4-Bromo-2-methyl-6-(trifluoromethyl)aniline

HRID 491147ノート

反応式

HRID 491147 の反応式
[Br:1]Br.[CH3:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:5]=1[NH2:14].C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[Br:1][C:8]1[CH:7]=[C:6]([C:10]([F:11])([F:12])[F:13])[C:5]([NH2:14])=[C:4]([CH3:3])[CH:9]=1

参加物

5

反応物 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 133182332-Amino-3-methylbenzotrifluoride

生成物 1

HCID 674070344-Bromo-2-methyl-6-(trifluoromethyl)aniline

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

Under a nitrogen atmosphere a solution of 11.0 mL (214 mmol) bromine in 100 mL chloroform was added dropwise to a solution of 35.8 g (204 mmol) 2-methyl-6-trifluoromethyl-phenylamine in 350 mL chloroform and after the end of the addition the reaction mixture was stirred for 3 h at RT. Saturated NaHCO3 solution was added with stirring, the mixture was stirred for a further 20 min at RT, the organic phase was separated off and dried over Na2SO4. After the desiccant and solvent had been eliminated the product was obtained as an oil, which was further reacted without purification.

後処理

  1. additionafter the end of the addition the reaction mixture
  2. stirringwith stirring
  3. stirringthe mixture was stirred for a further 20 min at RT
  4. customthe organic phase was separated off
  5. dry with materialdried over Na2SO4
  6. customwas obtained as an oil, which
  7. customwas further reacted without purification

出典と根拠

ORDレコード
ord-b14d31bb223343a5b15d6fe37075c20b
出典データセット
uspto-grants-2009_05
特許番号
US07528129B2

反応ノート

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