3-Nitro-biphenyl-4-acetic acid → 6-Phenyl-1,3-dihydro-indol-2-one
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][C:11](O)=[O:12])([O-])=O>C(O)(=O)C.[Fe]>[C:14]1([C:6]2[CH:5]=[C:4]3[C:9]([CH2:10][C:11](=[O:12])[NH:1]3)=[CH:8][CH:7]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1参加物
4
実験手順
Iron chips (2.6 g) were added all at once to 4.5 g of 3-nitrobiphenyl-4-acetic acid in 40 mL of acetic acid. The mixture was heated to reflux for 2 hours, concentrated to dryness and taken up in ethyl acetate. The solids were removed by filtration and the filtrate was washed twice with 1N hydrochloric acid and brine and dried over anhydrous sodium sulfate. The filtrate was concentrated to give 3.4 g (93% yield) of 6-phenyl-2-oxindole as a light brown solid.
後処理
- temperatureThe mixture was heated
- temperatureto reflux for 2 hours
- concentrationconcentrated to dryness
- customThe solids were removed by filtration
- washthe filtrate was washed twice with 1N hydrochloric acid and brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-d27c432970db48f6aa761702e7d002d4
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06706709B2
反応ノート
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