HCID 178418361、化合物 → Methyl 5-amino-1H-pyrazole-3-carboxylate

HRID 491394ノート

反応式

HRID 491394 の反応式
[N+:1]([C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1

参加物

5

反応物 2

HCID 178418361HCID 178418361、化合物HCID 178498471HCID 178498471、化合物

生成物 1

HCID 18445864Methyl 5-amino-1H-pyrazole-3-carboxylate収率 111.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A suspension of methyl 3-nitro-1H-pyrazole-5-carboxylate (10 g, 58.4 mmol) and 10% Pd on charcoal (1.2 g) in methanol (150 Ml) was stirred under 50 psi pressure of hydrogen gas for 16 h. The reaction mixture was filtered over a bed of Celite and the filtrate was concentrated to give 9.2 g of methyl 3-amino-1H-pyrazole-5-carboxylate which was used as such in the next reaction. MS (ESI) m/z 142.3 (M+H).

後処理

  1. filtrationThe reaction mixture was filtered over a bed of Celite
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-6d85ddd4f1b74951bd0bdff023564b68
出典データセット
uspto-grants-2009_05
特許番号
US07531539B2

反応ノート

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