ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Water → Ethyl 6-(2,3-dichlorobenzyl)-1,4-dihydro-8-fluoro-1-(2-hydroxyethyl)-4-oxo-3-quinolinecarboxylate

HRID 491524
ノート
印刷プレビュー

反応式

HRID 491524 の反応式
[Cl:1][C:2]1[C:35]([Cl:36])=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][C:5]1[CH:6]=[C:7]2[C:12](=[C:13]([F:15])[CH:14]=1)[N:11]([CH2:16][CH2:17][O:18][Si](C(C)(C)C)(C)C)[CH:10]=[C:9]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[C:8]2=[O:31].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.O>C1COCC1>[Cl:1][C:2]1[C:35]([Cl:36])=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][C:5]1[CH:6]=[C:7]2[C:12](=[C:13]([F:15])[CH:14]=1)[N:11]([CH2:16][CH2:17][OH:18])[CH:10]=[C:9]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[C:8]2=[O:31]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 962WaterHCID 2724141Tetrabutylammonium FluorideHCID 23083923Ethyl 6-(2,3-dichlorobenzyl)-1,4-dihydro-8-fluoro-1-[2-(tert-butyldimethylsilyloxy)ethyl]-4-oxo-3-quinolinecarboxylate

生成物 1

HCID 23083944Ethyl 6-(2,3-dichlorobenzyl)-1,4-dihydro-8-fluoro-1-(2-hydroxyethyl)-4-oxo-3-quinolinecarboxylate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran
溶媒

実験手順

Ethyl 6-(2,3-dichlorobenzyl)-1,4-dihydro-8-fluoro-1-[2-(tert-butyldimethylsilyloxy)ethyl]-4-oxo-3-quinolinecarboxylate (350 mg, 0.63 mmol) obtained in Step 5 was dissolved in THF (25 ml), tetrabutylammonium fluoride (1M THF solution; 1.9 ml, 1.9 mmol) was added, and the mixture was stirred at room temperature for 1 hr. Water was added to the reaction mixture, the precipitated solid was collected by filtration, which was washed with water and vacuum dried to give the object product (279 mg, yield quantitative) as a pale-yellow solid.

後処理

  1. filtrationthe precipitated solid was collected by filtration, which
  2. washwas washed with water and vacuum
  3. customdried
  4. customto give
  5. customthe object product (279 mg, yield quantitative) as a pale-yellow solid

出典と根拠

ORDレコード
ord-5412ad45f48943879f13cb15774800b9
出典データセット
uspto-grants-2009_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07531554B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート