Hydrochloric Acid → (3-((Methylsulfonyl)amino)phenyl)acetic acid

HRID 491538ノート

反応式

HRID 491538 の反応式
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([O:15]C)=[O:14])[CH:9]=[CH:10][CH:11]=1)(=[O:4])=[O:3].[OH-].[Na+].Cl.O>C(O)C>[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:10][CH:11]=1)(=[O:4])=[O:3]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 21071300Methyl 3-(methanesulfonylamino)phenylacetate

生成物 1

HCID 2773885(3-((Methylsulfonyl)amino)phenyl)acetic acid収率 92%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Methyl 3-(methanesulfonylamino)phenylacetate (3.36 g, 13.8 mmol) was dissolved in ethanol (16 mL) and 1N NaOH (30 mL) added. The reaction was stirred for 1 hour, then 1N HCl (50 mL) and water (50 mL) were added. The product was extracted into ethyl acetate (3×50 mL) and the combined extracts were washed with water and brine and dried (MgSO4). Removal of solvent afforded 3-(methanesulfonylamino)phenylacetic acid (2.90 g, 92%). 1H NMR (DMSO-6) δ 12.32 (1H, br), 9.69 (1H, br), 7.26 (1H, dd), 7.10 (2H, m), 7.00 (1H, d), 6.57 (1H, s), 3.54 (2H, s), 2.97 (3H, s).

後処理

  1. extractionThe product was extracted into ethyl acetate (3×50 mL)
  2. washthe combined extracts were washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customRemoval of solvent

出典と根拠

ORDレコード
ord-282cd812abd84317a7db81e210843cb3
出典データセット
uspto-grants-2009_05
特許番号
US07531556B2

反応ノート

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