関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 4-Chloroquinoline | HCID 69140 | — |
| 反応物 | 4-Amino-2-Nitrophenol | HCID 3417419 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2-Nitro-4-(quinolin-4-ylamino)-phenol | HCID 69018454 | — |
反応手順
TFA (0.57 mL) was added to a suspension of 4-chloroquinoline (0.48 mg, 2.9 mmol) and 4-amino-2-nitrophenol (0.45 g, 2.9 mmol) in i-PrOH (4 mL) was added at RT. The reaction was heated to 130° C. in a sealed tube for 2 h. A solid precipitated upon cooling. The solid was filtered out and washed with i-PrOH to give 2-nitro-4-(quinolin-4-ylamino)-phenol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07531553B2 |
|---|
| 出典データセット | uspto-grants-2009_05 |
|---|
| ORD ID | ord-d147708c38884f24a17fa4db806b74d8 |
|---|
| 出典メモ | uspto-grants-2009_05 |
|---|
