反应详情

温度

130 °C

TFA (0.57 mL) was added to a suspension of 4-chloroquinoline (0.48 mg, 2.9 mmol) and 4-amino-2-nitrophenol (0.45 g, 2.9 mmol) in i-PrOH (4 mL) was added at RT. The reaction was heated to 130° C. in a sealed tube for 2 h. A solid precipitated upon cooling. The solid was filtered out and washed with i-PrOH to give 2-nitro-4-(quinolin-4-ylamino)-phenol.

1. additionwas added at RT
2. customA solid precipitated
3. temperatureupon cooling
4. filtrationThe solid was filtered out
5. washwashed with i-PrOH