HCID 178454208、化合物 → HCID 178511821、化合物

HRID 491879ノート

反応式

HRID 491879 の反応式
[CH2:1]([O:8][C:9]([C@H:11]1[CH2:16][CH2:15][C@@H:14]([N:17]([CH2:37][CH2:38][O:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C:18](=[O:36])[CH2:19][CH2:20][C@H:21]([NH:28]C(OC(C)(C)C)=O)[CH:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O>[CH2:1]([O:8][C:9]([C@H:11]1[CH2:16][CH2:15][C@@H:14]([N:17]([C:18](=[O:36])[CH2:19][CH2:20][C@H:21]([NH2:28])[CH:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[CH2:37][CH2:38][O:39][CH2:40][C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 178454208HCID 178454208、化合物

生成物 1

HCID 178511821HCID 178511821、化合物

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 4-{(2-benzyloxy-ethyl)-[4-tert-butoxycarbonylamino-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-amino}-cis-cyclohexanecarboxylic acid benzyl ester (4.8 g, 7.5 mmol) in TFA (5% in CH2Cl2, 100 mL) was stirred at room temperature overnight. The solvent and most of the TFA was evaporated, and EtOAc (300 mL) was added to the residue. The solution was washed with aq. NaHCO3 and aq. NaCl. The organic layer was dried with MgSO4 and evaporated to yield 4-[[4-amino-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-(2-benzyloxy-ethyl)-amino]-cis-cyclohexanecarboxylic acid benzyl ester as a light brown oil.

後処理

  1. customThe solvent and most of the TFA was evaporated
  2. additionEtOAc (300 mL) was added to the residue
  3. washThe solution was washed with aq. NaHCO3 and aq. NaCl
  4. dry with materialThe organic layer was dried with MgSO4
  5. customevaporated

出典と根拠

ORDレコード
ord-eeb12315351c431192f1175cbc824ffb
出典データセット
uspto-grants-2009_05
特許番号
US07531545B2

反応ノート

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