Acetone → 4-(5-Fluoro-2-methylphenyl)-3-buten-2-one

HRID 49189ノート

反応式

HRID 49189 の反応式
[OH-].[Na+].O.[F:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:12]=1)[CH:10]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[F:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:10]=[CH:14][C:15](=[O:16])[CH3:17])[CH:12]=1

参加物

5

反応物 4

HCID 180Acetone2 回HCID 962WaterHCID 14798Sodium HydroxideHCID 27590125-Fluoro-2-methylbenzaldehyde

生成物 1

HCID 540396424-(5-Fluoro-2-methylphenyl)-3-buten-2-one

実験手順

A mixture of acetone (80 ml), sodium hydroxide (3.7 g) and water (100 ml) was treated at room temperature dropwise with a solution of 5-fluoro-2-methylbenzaldehyde (11.5 g) in acetone (30 ml) and stirred at the same temperature for 1 hour. Acetone was distilled off under reduced pressure, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine and concentrated under reduced pressure to obtain 4-(5-fluoro-2-methylphenyl)-3-buten-2-one (13.4 g).

後処理

  1. distillationAcetone was distilled off under reduced pressure
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed successively with water and saturated brine
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-79e6aaa0f0ab48a2bfc1ef78b562a897
出典データセット
uspto-grants-2004_03
特許番号
US06706732B1

反応ノート

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