Ethanol → 2-[(5-Amino-2-phenoxy-pyridin-4-ylmethyl)-amino]-3,N-dimethyl-N-phenethyl-butyramide

HRID 491917ノート

反応式

HRID 491917 の反応式
[CH3:1][CH:2]([CH3:34])[CH:3]([NH:16][CH2:17][C:18]1[C:23]([N+:24]([O-])=O)=[CH:22][N:21]=[C:20]([O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:19]=1)[C:4]([N:6]([CH3:15])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5].C(O)C>[Pd].C(OCC)(=O)C>[NH2:24][C:23]1[C:18]([CH2:17][NH:16][CH:3]([CH:2]([CH3:34])[CH3:1])[C:4]([N:6]([CH3:15])[CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:5])=[CH:19][C:20]([O:27][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)=[N:21][CH:22]=1

参加物

5

反応物 2

HCID 702EthanolHCID 670236673,N-Dimethyl-2-[(5-nitro-2-phenoxy-pyridin-4-ylmethyl)-amino]-N-phenethyl-butyramide

生成物 1

HCID 670236882-[(5-Amino-2-phenoxy-pyridin-4-ylmethyl)-amino]-3,N-dimethyl-N-phenethyl-butyramide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 3,N-dimethyl-2-[(5-nitro-2-phenoxy-pyridin-4-ylmethyl)-amino]-N-phenethyl-butyramide (2.1 g, 1.38 mmol), 10% Pd on carbon (2 g), ethanol (75 mL) and ethyl acetate (75 mL) were shaken under a hydrogen atmosphere (50 psi). After 2 hours, the hydrogen was evacuated and the bottle was purged with nitrogen. The resulting mixture was filtered through glass fiber filter paper and the solvent evaporated under low pressure to yield a solid.

後処理

  1. customthe hydrogen was evacuated
  2. customthe bottle was purged with nitrogen
  3. filtrationThe resulting mixture was filtered through glass fiber
  4. filtrationfilter paper
  5. customthe solvent evaporated under low pressure
  6. customto yield a solid

出典と根拠

ORDレコード
ord-b05a5b80daea44fda9204fffbd105cb7
出典データセット
uspto-grants-2009_05
特許番号
US07531545B2

反応ノート

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