Acetone → 4-(2,5-Difluorophenyl)but-3-en-2-one
反応式
[OH-].[Na+].O.[F:4][C:5]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=1[CH:7]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[F:4][C:5]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=1[CH:7]=[CH:14][C:15](=[O:16])[CH3:17]参加物
5
実験手順
A mixture of acetone (45 ml), sodium hydroxide (3.1 g) and water (230 ml) was combined at room temperature with a solution of 2,5-difluorobenzaldehyde (10.0 g) in acetone (10 ml) and stirred at the same temperature for 30 minutes. Acetone was distilled off under reduced pressure and extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine and concentrated under reduced pressure to obtain 4-(2,5-difluorophenyl)-3-buten-2-one (13.8 g).
後処理
- distillationAcetone was distilled off under reduced pressure
- extractionextracted with ethyl acetate
- washThe organic layer was washed successively with water and saturated brine
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-8199b19ea870431cb22c15b0a484ca72
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06706732B1
反応ノート
読み込み中…