Acetone → 4-(2,5-Difluorophenyl)but-3-en-2-one

HRID 49203

反応式

HRID 49203 の反応式
[OH-].[Na+].O.[F:4][C:5]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=1[CH:7]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[F:4][C:5]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=1[CH:7]=[CH:14][C:15](=[O:16])[CH3:17]

参加物

5

反応物 4

HCID 180Acetone2 回HCID 962WaterHCID 14798Sodium HydroxideHCID 1376632,5-Difluorobenzaldehyde

生成物 1

HCID 14817594-(2,5-Difluorophenyl)but-3-en-2-one

実験手順

A mixture of acetone (45 ml), sodium hydroxide (3.1 g) and water (230 ml) was combined at room temperature with a solution of 2,5-difluorobenzaldehyde (10.0 g) in acetone (10 ml) and stirred at the same temperature for 30 minutes. Acetone was distilled off under reduced pressure and extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine and concentrated under reduced pressure to obtain 4-(2,5-difluorophenyl)-3-buten-2-one (13.8 g).

後処理

  1. distillationAcetone was distilled off under reduced pressure
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed successively with water and saturated brine
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-8199b19ea870431cb22c15b0a484ca72
出典データセット
uspto-grants-2004_03
特許番号
US06706732B1

関連ノート

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