1-Hydroxybenzotriazole → {[(6-Benzenesulfonylamino-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester

HRID 492095

反応式

[NH2:1][CH2:2][CH:3]1[CH2:12][CH2:11][CH2:10][C:9]2[CH:8]=[C:7]([NH:13][S:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:16])=[O:15])[CH:6]=[CH:5][C:4]1=2.[CH2:23]([O:30][C:31]([N:33]([CH2:35][C:36](O)=[O:37])[CH3:34])=[O:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.ON1C2C=CC=CC=2N=N1.CC[N+](CCCN(C)C)=C=N>C(Cl)Cl.C(N(CC)CC)C>[CH2:23]([O:30][C:31](=[O:32])[N:33]([CH2:35][C:36](=[O:37])[NH:1][CH2:2][C:3]1[C:4]2[C:9](=[CH:8][C:7]([NH:13][S:14]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)(=[O:16])=[O:15])=[CH:6][CH:5]=2)[CH:10]=[CH:11][CH:12]=1)[CH3:34])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

実験手順

A mixture of N-(5-Aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide, (Benzyloxycarbonyl-methyl-amino)-acetic acid, 1-hydroxybenzotriazole, N-(3-dimethylaminopropyl)-N-ethylcarbodiimide and triethylamine in methylene chloride is stirred at room temperature. The reaction is quenched by addition of water, and the mixture is eluted through silica gel to give {[(6-Benzenesulfonylamino-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester.

後処理

customThe reaction is quenched by addition of water
washthe mixture is eluted through silica gel

出典と根拠

ORDレコード: ord-4366e0d83b2f484e97dba99d5a6ef4ff
出典データセット: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07531577B2

反応式

参加物

反応物 4

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

関連ノート