3,3-Dimethylbutylamine → 6-{4-[(3,3-Dimethyl-butylamino)-methyl]-2-fluoro-6-methoxy-phenoxy}-nicotinamide

HRID 492571ノート

反応式

HRID 492571 の反応式
[F:1][C:2]1[CH:17]=[C:16]([CH:18]=O)[CH:15]=[C:14]([O:20][CH3:21])[C:3]=1[O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][N:6]=1.[CH3:22][C:23]([CH3:28])([CH3:27])[CH2:24][CH2:25][NH2:26].[BH4-].[Na+]>>[CH3:22][C:23]([CH3:28])([CH3:27])[CH2:24][CH2:25][NH:26][CH2:18][C:16]1[CH:15]=[C:14]([O:20][CH3:21])[C:3]([O:4][C:5]2[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][N:6]=2)=[C:2]([F:1])[CH:17]=1

参加物

4

反応物 3

HCID 197093,3-DimethylbutylamineHCID 4311764Sodium borohydrideHCID 597302826-(2-Fluoro-4-formyl-6-methoxy-phenoxy)-nicotinamide

生成物 1

HCID 100908706-{4-[(3,3-Dimethyl-butylamino)-methyl]-2-fluoro-6-methoxy-phenoxy}-nicotinamide収率 80.1%

実験手順

Using a method similar to Example 710, Step 4, using 6-(2-fluoro-4-formyl-6-methoxy-phenoxy)-nicotinamide (250 mg, 0.861 mmol), 3,3-dimethyl-butylamine (104 mg, 1.03 mmol), and NaBH4 (49 mg, 1.29 mmol) gave the title compound (259 mg) as a white solid. Mass spectrum (ion spray): m/z=376 (M+1); 1HNMR (DMSO-d6): 8.50 (s, 1H), 8.23 (d, 1 μl), 7.98 (s, 1H), 7.44 (s, 1H), 7.13 (d, 1H), 6.96 (s, 1H), 6.89 (d, 1H), 3.71 (s, 3H), 3.68 (s, 2H), 2.51 (t, 2H), 1.37 (t, 2H), 0.86 (s, 9H).

出典と根拠

ORDレコード
ord-48632683c371462bb8e54a35de18af81
出典データセット
uspto-grants-2009_05
特許番号
US07531557B2

反応ノート

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