Hydrochloric Acid → 1-(7-Amino-5-bromoindolin-1-yl)ethanone
反応式
C(O)C.[C:4]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([Br:19])=[CH:13][C:14]=2[N+:16]([O-])=O)[CH2:9][CH2:8]1)(=[O:6])[CH3:5].Cl>[Fe].O>[C:4]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([Br:19])=[CH:13][C:14]=2[NH2:16])[CH2:9][CH2:8]1)(=[O:6])[CH3:5]参加物
6
実験手順
To a mixed solution of ethanol (400 ml) and water (100 ml), were added N-acetyl-5-bromo-7-nitroindoline (133.1 g), iron powder (10 mesh; 75 g) and concentrated hydrochloric acid (5 ml), and the mixture was subjected to refluxing for 5 hours with vigorous stirring. The reaction mixture was filtered by suction while hot to remove insoluble matter, and then the filtrate thereof was concentrated and cooled on standing to give the intended compound 38.3 g (32.2%) as a brown needle crystal. M.P.: 154°-155° C.
後処理
- temperatureto refluxing for 5 hours with vigorous stirring
- filtrationThe reaction mixture was filtered by suction while hot
- customto remove insoluble matter
- concentrationthe filtrate thereof was concentrated
- temperaturecooled
出典と根拠
- ORDレコード
- ord-fa8c1a5973204abeab956b536c71aec8
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05242912
反応ノート
読み込み中…