(3Z)-(5S)-5,9-Dimethyl-dec-3-ene-1,9-diol → (R)-5,9-dimethyl-decane-1,9-diol
反応式
[CH3:1][C@@H:2]([CH2:8][CH2:9][CH2:10][C:11]([CH3:14])([OH:13])[CH3:12])/[CH:3]=[CH:4]\[CH2:5][CH2:6][OH:7].[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][C@@H:2]([CH2:8][CH2:9][CH2:10][C:11]([CH3:14])([OH:13])[CH3:12])[CH2:3][CH2:4][CH2:5][CH2:6][OH:7]参加物
5
実験手順
To a solution of diol 13 (55 mg, 0.27 mmol) in ethyl acetate (10 mL) was added Pd/C (10%, 50 mg). The reaction mixture was stirred for 18 hours under a continuous stream of hydrogen at room temperature. The mixture was then filtered, and the solvent was evaporated under reduced pressure. The crude oily product was chromatographed on silica Sep-Pak cartridge eluted with hexane/EtOAc (8:2) to give an oily diol 14 (55 mg, 45%).
後処理
- filtrationThe mixture was then filtered
- customthe solvent was evaporated under reduced pressure
- customThe crude oily product was chromatographed on silica Sep-Pak cartridge
- washeluted with hexane/EtOAc (8:2)
出典と根拠
- ORDレコード
- ord-3f4ed69f44ae41e8a173d4075ec1f021
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07534777B2
反応ノート
読み込み中…