Sodium Hydroxide → 5-Methoxybenzofuran-2-carboxylic acid

HRID 493171

反応式

HRID 493171 の反応式
C([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:9]=2[CH:10]=1)=[O:5])C.[OH-].[Na+]>C1COCC1.C(O)C>[CH3:16][O:15][C:12]1[CH:13]=[CH:14][C:8]2[O:7][C:6]([C:4]([OH:5])=[O:3])=[CH:10][C:9]=2[CH:11]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 5212832-Benzofurancarboxylic acid, 5-methoxy-, ethyl ester

生成物 1

HCID 2886385-Methoxybenzofuran-2-carboxylic acid収率 98.1%

試薬・触媒・溶媒 1

HCID 21873804Tetrahydrofuran ethanol溶媒

実験手順

The above prepared 5-methoxy-benzofuran-2-carboxylic acid ethyl ester (0.500 g, 2.27 mmol) was dissolved in 4.6 mL of THF/ethanol=1/1 and treated with 2.27 mL of aq. NaOH (3M, 3 eq.). The mixture was stirred for 2 h at ambient temperature and was then poured onto crashed ice/AcOEt/HCl dil.; the organic layer was washed with water, dried over sodium sulfate, and evaporated to dryness to leave 0.428 g of the title acid as off-white solid.

後処理

  1. additionwas then poured
  2. washthe organic layer was washed with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-5ad61bf6ee8540288b52aa2db09a5317
出典データセット
uspto-grants-2009_05
特許番号
US07534788B2

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