Hydrochloric Acid → 6-Hydroxyquinoline-2-carboxylic acid

HRID 493423ノート

反応式

HRID 493423 の反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([OH:15])=[O:14])[CH:7]=[CH:6]2.[OH-].[NH4+].Cl>Br.O>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([OH:15])=[O:14])[CH:7]=[CH:6]2

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 111832986-methoxyquinoline-2-carboxylic Acid

生成物 1

HCID 133367806-Hydroxyquinoline-2-carboxylic acid

試薬・触媒・溶媒 2

HCID 260Hydrogen Bromide溶媒HCID 962Water溶媒

反応条件

温度
125 °C

実験手順

6-Methoxy-quinoline-2-carboxylic acid (4 g, 0.019 mol) was suspended in hydrobromic acid 48% in water (80 ml) and the mixture was heated at 125° C. overnight. After cooling to 0° C. ammonium hydroxide was added until the pH was 6-7 followed by addition of HCl until the pH was 3-4 and the compound precipitated. The solid was filtrated, washed with water and dried under vacuum to yield 3.5 g (0.0185 mol, 97% of theory) of the title compound as a yellow solid MS (m/e)=190.1 (M+H)+.

後処理

  1. additionwas added until the pH was 6-7
  2. customthe compound precipitated
  3. filtrationThe solid was filtrated
  4. washwashed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-9c87f3eaade24b8497bce2b060f9057e
出典データセット
uspto-grants-2009_05
特許番号
US07534891B2

反応ノート

読み込み中…