Benzyl (3R)-6-(4-hydroxyphenyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-ylcarbamate → (3R)-3-Amino-6-(4-hydroxyphenyl)azepan-2-one

HRID 493629

反応式

HRID 493629 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:14][NH:13][C:12](=[O:15])[C@H:11]([NH:16]C(=O)OCC3C=CC=CC=3)[CH2:10][CH:9]=2)=[CH:4][CH:3]=1>[Pd].C1(C)C=CC=CC=1.CO>[NH2:16][C@@H:11]1[CH2:10][CH2:9][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=2)[CH2:14][NH:13][C:12]1=[O:15]

参加物

5

反応物 1

HCID 86595031Benzyl (3R)-6-(4-hydroxyphenyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-ylcarbamate

生成物 1

HCID 60037861(3R)-3-Amino-6-(4-hydroxyphenyl)azepan-2-one

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 1140Toluene溶媒

実験手順

10% Palladium on carbon (10 mg) was added to a solution of benzyl (3R)-6-(4-hydroxyphenyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-ylcarbamate (15 mg, 0.043 mmol) in toluene (5 mL) and methanol (1 mL). The reaction vessel is evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 18 h, the mixture was filtered and concentrated. MS 221 (M+1).

後処理

  1. customThe reaction vessel is evacuated
  2. additionback-filled with nitrogen (3×)
  3. additionback-filled with hydrogen (1 atm)
  4. filtrationthe mixture was filtered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-858cc534b1fe40ff8111fcda03704223
出典データセット
uspto-grants-2009_05
特許番号
US07534784B2

関連ノート

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