1,4-Cyclohexadiene → 2-[4-(4-Methyl-oxazol-2-yl)-phenoxy]-ethylamine

HRID 49373

反応式

HRID 49373 の反応式
C(OC(=O)[NH:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[O:21][CH:22]=[C:23]([CH3:25])[N:24]=2)=[CH:16][CH:15]=1)C1C=CC=CC=1.C1CC=CCC=1>CO.[Pd]>[CH3:25][C:23]1[N:24]=[C:20]([C:17]2[CH:18]=[CH:19][C:14]([O:13][CH2:12][CH2:11][NH2:10])=[CH:15][CH:16]=2)[O:21][CH:22]=1

参加物

5

反応物 2

HCID 123431,4-CyclohexadieneHCID 12986049{2-[4-(4-Methyl-oxazol-2-yl)-phenoxy]-ethyl}-carbamic acid benzyl ester2 回

生成物 1

HCID 120719972-[4-(4-Methyl-oxazol-2-yl)-phenoxy]-ethylamine収率 90%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

The title compound of Example 1, {2-[4-(4-Methyl-oxazol-2-yl)-phenoxy]-ethyl}-carbamic acid benzyl ester, (166 mg, 0.47 mmol) was dissolved in methanol (5 ml) and 10% Pd/C (50 mg) and 1,4-cyclohexadiene (192 mg, 2.4 mmol) were added to the resulting solution. The mixture was allowed to stir for about sixteen hours, and then it was filtered through diatomaceous earth, and the filter pad was washed with methanol. The filtrate was concentrated in vacuo to dryness, and the resulting material (92 mg, 90% yield), which was determined to be pure by 1H NMR, was used directly without further purification. LRMS ([M+H]+)=219.2.

後処理

  1. filtrationit was filtered through diatomaceous earth
  2. washthe filter pad was washed with methanol
  3. concentrationThe filtrate was concentrated in vacuo to dryness

出典と根拠

ORDレコード
ord-b8a149b034b44dceb24886fdb7e850f7
出典データセット
uspto-grants-2004_03
特許番号
US06706743B2

関連ノート

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