Hydrochloric Acid → 2-[4-(2-Phenyl-thiazol-4-yl)-phenyl]-ethylamine

HRID 49383

反応式

HRID 49383 の反応式
[C:1]1([C:7]2[S:8][CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][NH:20]C(=O)C)=[CH:14][CH:13]=3)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[OH-].[Na+]>>[C:1]1([C:7]2[S:8][CH:9]=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][NH2:20])=[CH:16][CH:17]=3)[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 9343045N-[2-[4-(2-Phenyl-thiazol-4-yl)-phenyl]-ethyl}-acetamide

生成物 1

HCID 185236422-[4-(2-Phenyl-thiazol-4-yl)-phenyl]-ethylamine収率 85%

反応条件

温度
120 °C

実験手順

In a round-bottomed flask, N-{2-[4-(2-phenyl-thiazol-4-yl)-phenyl]-ethyl}-acetamide (838 mg, 2.60 mmol) was added to 5.0 ml of concentrated HCl and the resulting solution was heated to about 120° C. for about sixteen hours. The solution was then cooled to about 0° C., brought to pH 12 with 5M sodium hydroxide, and extracted with four portions of methylene chloride. The combined organic extracts were then washed with brine, dried over magnesium sulfate, and concentrated in vacuo. The crude material was purified by column chromatography (silica gel; methylene chloride to 20% methanol/methylene chloride) to afford the product (617 mg, 85% yield). LRMS ([M+H]+)=281.2.

後処理

  1. temperatureThe solution was then cooled to about 0° C.
  2. extractionextracted with four portions of methylene chloride
  3. washThe combined organic extracts were then washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo
  6. customThe crude material was purified by column chromatography (silica gel; methylene chloride to 20% methanol/methylene chloride)

出典と根拠

ORDレコード
ord-f6dc22ce7e034bc1be1448ef773ce304
出典データセット
uspto-grants-2004_03
特許番号
US06706743B2

関連ノート

読み込み中…