3-Bromobenzophenone → (3-Bromophenyl)(phenyl)methanol

HRID 494035

反応式

HRID 494035 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].[BH4-].[Na+]>CO.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[OH:6])[CH:13]=[CH:14][CH:15]=1

参加物

5

反応物 2

HCID 705483-BromobenzophenoneHCID 4311764Sodium borohydride

生成物 1

HCID 285827(3-Bromophenyl)(phenyl)methanol収率 79%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of 3-bromobenzophenone (1.00 g, 4 mmol) in MeOH (15 mL) was added sodium borohydride (0.3 mL, 8 mmol) portionwise at rt and the suspension was stirred at rt for 1-24 h. The reaction was diluted slowly with water and extracted with CH2Cl2. The organic layer was washed successively with water, brine, dried over Na2SO4, and concentrated to give the title compound as oil (0.8 g, 79%), which was used in the next reaction without further purification. MS (ESI, pos. ion) m/z: 247.1 (M−OH).

後処理

  1. extractionextracted with CH2Cl2
  2. washThe organic layer was washed successively with water, brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-752dba6fdf074646a84b38f7952738bd
出典データセット
uspto-grants-2009_05
特許番号
US07538114B2

関連ノート

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