Sodium borohydride → 2-(4-fluorobenzyl)-4-(hydroxymethyl)-10-methoxy-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

HRID 494125ノート

反応式

HRID 494125 の反応式
[F:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]3[C:14]([O:23][CH3:24])=[C:15]4[C:20](=[O:21])[N:19]([CH3:22])[CH2:18][CH2:17][N:16]4[C:10]=3[C:9]([C:25](OC)=[O:26])=[N:8]2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[F:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]3[C:14]([O:23][CH3:24])=[C:15]4[C:20](=[O:21])[N:19]([CH3:22])[CH2:18][CH2:17][N:16]4[C:10]=3[C:9]([CH2:25][OH:26])=[N:8]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 68865248Methyl 2-(4-fluorobenzyl)-10-methoxy-8-methyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxylate

生成物 1

HCID 688646802-(4-fluorobenzyl)-4-(hydroxymethyl)-10-methoxy-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of methyl 2-(4-fluorobenzyl)-10-methoxy-8-methyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-4-carboxylate (0.10 g, 0.24 mmol) in methanol (4 mL) was treated with sodium borohydride (9 mg, 0.24 mmol). After stirring at room temperature for 30 minutes, the reaction mixture was concentrated under vacuum to half the volume. The white solid precipitated was filtered and air dried to provide the title alcohol.

後処理

  1. concentrationthe reaction mixture was concentrated under vacuum to half the volume
  2. customThe white solid precipitated
  3. filtrationwas filtered
  4. customair dried

出典と根拠

ORDレコード
ord-084a15db01844241b3cd0c7424b958c9
出典データセット
uspto-grants-2009_05
特許番号
US07538112B2

反応ノート

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