7-Nitroquinoline → 7-Aminoquinoline
反応式
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH:10]=[N:11]2)=[CH:6][CH:5]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH:10]=[N:11]2)=[CH:6][CH:5]=1参加物
4
実験手順
A mixture of 7-nitroquinoline (D54) (0.65 g, 3.71 mmol) and 10% palladium on charcoal (65 mg, 54% water) in methanol (20 ml) was hydrogenated at 1 atm. and ambient temperature for until complete by tlc. The catalyst was filtered off and washed with further methanol. The combined filtrated and washings were concentrated in vacuo to give the title compound as a brown solid (0.53 g). 1H NMR (400 MHz, CDCl3) δ (ppm): 8.75 (dd, 1H), 7.98 (dd, 1H), 7.62 (d, 1H), 7.21 (d, 1H), 7.14 (dd, 1H), 6.99 (dd, 1H), 4.07 (br, 2H).
後処理
- customwas hydrogenated at 1 atm. and ambient temperature
- filtrationThe catalyst was filtered off
- washwashed with further methanol
- filtrationThe combined filtrated
- concentrationwashings were concentrated in vacuo
出典と根拠
- ORDレコード
- ord-2aa36f04dfe5494f85b06189f667b4b3
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07538121B2
反応ノート
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