ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Hydrogen Bromide → methyl 2-((S)-1-amino-2-methylpropyl)-5-(7-bromo-1H-indol-3-yl)oxazole-4-carboxylate hydrobromide

HRID 494377
ノート
印刷プレビュー

反応式

HRID 494377 の反応式
Br.C(OC([NH:12][C@H:13]([C:17]1[O:18][C:19]([C:26]2[C:34]3[C:29](=[C:30]([Br:35])[CH:31]=[CH:32][CH:33]=3)[NH:28][CH:27]=2)=[C:20]([C:22]([O:24][CH3:25])=[O:23])[N:21]=1)[CH:14]([CH3:16])[CH3:15])=O)C1C=CC=CC=1.CC(OC)(C)C>C(O)(=O)C>[BrH:35].[NH2:12][C@H:13]([C:17]1[O:18][C:19]([C:26]2[C:34]3[C:29](=[C:30]([Br:35])[CH:31]=[CH:32][CH:33]=3)[NH:28][CH:27]=2)=[C:20]([C:22]([O:24][CH3:25])=[O:23])[N:21]=1)[CH:14]([CH3:16])[CH3:15]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 15413tert-Butyl methyl etherHCID 59595035methyl 2-((S)-1-(benzyloxycarbonylamino)-2-methylpropyl)-5-(7-bromo-1H-indol-3-yl)oxazole-4-carboxylate

生成物 1

HCID 66889567methyl 2-((S)-1-amino-2-methylpropyl)-5-(7-bromo-1H-indol-3-yl)oxazole-4-carboxylate hydrobromide収率 153.1%

試薬・触媒・溶媒 1

HCID 176
Acetic Acid
溶媒

実験手順

To 33% HBr in acetic acid (1.33 L) was added the title compound of Example 5 (403.4 g, 766 mmol) and the stirred vigorously for 1 hour and 20 min. The mixture was slowly and carefully added to MTBE (12 L) with external cooling and strong agitation. The mixture was stirred for 1 hour at 0° C. and filtered under N2. The hygroscopic solids were washed with MTBE (1 L) and dried to constant mass in a vacuum oven to yield the title compound (277.5 g, 76.5%) as a fine brown solid. 1H NMR (CDCl3): consistent with proposed structure.

後処理

  1. temperaturewith external cooling
  2. stirringThe mixture was stirred for 1 hour at 0° C.
  3. filtrationfiltered under N2
  4. washThe hygroscopic solids were washed with MTBE (1 L)
  5. customdried to constant mass in a vacuum oven

出典と根拠

ORDレコード
ord-01f361cb86be4320a5eae1291c8048e8
出典データセット
uspto-grants-2009_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07538129B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート