Ethanone, 1-(3,5-bis(phenylmethoxy)phenyl)- → 1-(3,5-Bis(phenylmethoxy)phenyl)-2-bromoethan-1-one

HRID 494417ノート

反応式

HRID 494417 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:23](=[O:25])[CH3:24])[CH:12]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br-:26].[Br-].[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1.CO>[CH2:16]([O:15][C:13]1[CH:12]=[C:11]([C:23](=[O:25])[CH2:24][Br:26])[CH:10]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:14]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

参加物

5

反応物 2

HCID 120098Ethanone, 1-(3,5-bis(phenylmethoxy)phenyl)-HCID 23500184Tetra-n-butylammonium tribromide

生成物 1

HCID 1200971-(3,5-Bis(phenylmethoxy)phenyl)-2-bromoethan-1-one

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a stirred solution of 1-[3,5-bis(benzyloxy)phenyl]ethanone (5 g, 15.04 mmol) in tetrahydrofuran (60 mL) and methanol (35 mL) was added tetrabutylammonium tribromide (7.25 g, 15.04 mmol) in tetrahydrofuran (20 mL) at room temperature. The reaction mixture was stirred for 24 hours and the solvent removed in vacuo. The residue was dissolved in ethyl acetate (100 mL) and washed with water (2×50 mL). The combined organic extracts were dried over magnesium sulfate and concentrated to afford the desired compound as a yellow oil in quantitative yield.

後処理

  1. customthe solvent removed in vacuo
  2. dissolutionThe residue was dissolved in ethyl acetate (100 mL)
  3. washwashed with water (2×50 mL)
  4. dry with materialThe combined organic extracts were dried over magnesium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-37b82bc9545047b0916a4cec67c3ded1
出典データセット
uspto-grants-2009_05
特許番号
US07538141B2

反応ノート

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