Hydrochloric Acid → Ethyl 2-(piperidin-4-yl)acetate

HRID 4949

反応式

HRID 4949 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:3][CH:2]=1.Cl>C(O)C.[H][H].[Pt]=O>[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][CH2:2]1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 736321Ethyl pyridine-4-acetate

生成物 1

HCID 2760465Ethyl 2-(piperidin-4-yl)acetate収率 162.3%

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒HCID 178418361HCID 178418361、化合物溶媒

実験手順

16.5 g (0.1 mol) Ethyl 4-pyridylacetate, 8.4 mL (0.1 mol) 12N hydrochloric acid and 2.5 g platinum oxide were dissolved in absolute ethanol and hydrogenated at 40 psi hydrogen on a Parr shaker. After 1 hour, the contents of the vessel were filtered and concentrated in vacuo yielding 27.79 g of ethyl 4-piperidinylacetate.

後処理

  1. filtrationthe contents of the vessel were filtered
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-4bf57d14da074ba286dc99dcf47db4ab
出典データセット
uspto-grants-1993_09
特許番号
US05242924

関連ノート

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