Acetone → 2,4-Bis(allyloxy)-1-ethylbenzene

HRID 495306ノート

反応式

HRID 495306 の反応式
[CH2:1]([C:3]1[CH:9]=[CH:8][C:6]([OH:7])=[CH:5][C:4]=1[OH:10])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:17](Br)[CH:18]=[CH2:19].[CH3:21][C:22]([CH3:24])=O>>[CH2:17]([O:10][C:4]1[CH:5]=[C:6]([O:7][CH2:24][CH:22]=[CH2:21])[CH:8]=[CH:9][C:3]=1[CH2:1][CH3:2])[CH:18]=[CH2:19]

参加物

5

反応物 4

HCID 180AcetoneHCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 179274-Ethylresorcinol

生成物 1

HCID 45498682,4-Bis(allyloxy)-1-ethylbenzene収率 95%

実験手順

4-Ethylresorcinol (10 g, 73 mmol) was dissolved in acetone (250 mL), and potassium carbonate (30 g, 220 mmol) and allyl bromide (15 mL, 170 mmol) were added thereto and heated under reflux for 4 hours. The reaction mixture was cooled to room temperature, then filtered through Celite, and the filtrate was concentrated under reduced pressure. The resulting residue was purified through silica gel column chromatography (ethyl acetate/n-hexane=1/9) to obtain 2,4-bis(allyloxy)-1-ethylbenzene (15 g, 95%).

後処理

  1. temperatureheated
  2. temperatureunder reflux for 4 hours
  3. filtrationfiltered through Celite
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customThe resulting residue was purified through silica gel column chromatography (ethyl acetate/n-hexane=1/9)

出典と根拠

ORDレコード
ord-a972cf91d66a4022bfea1f8451cc6534
出典データセット
uspto-grants-2009_05
特許番号
US07538241B2

反応ノート

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