Hydrochloric Acid → 6-(4-Piperidinyl)-4H-benzo[1,4]oxazin-3-one

HRID 495422

反応式

HRID 495422 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:15][CH2:14][C:13](=[O:16])[NH:12][C:11]=3[CH:17]=2)=[CH:3][CH:2]=1.Cl>CO.CCOCC.[Pt](=O)=O>[NH:1]1[CH2:2][CH2:3][CH:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:15][CH2:14][C:13](=[O:16])[NH:12][C:11]=3[CH:17]=2)[CH2:5][CH2:6]1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 223266866-(4-Pyridyl)-4H-benzo[1,4]oxazin-3-one

生成物 1

HCID 223267216-(4-Piperidinyl)-4H-benzo[1,4]oxazin-3-one収率 100.8%

試薬・触媒・溶媒 3

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

A solution of 6-(4-pyridyl)-4H-benzo[1,4]oxazin-3-one (0.57 g, 2.52 mmol), in methanol (15 mL) was treated with platinum (IV) oxide (50 mg, 0.22 mmol) and 1M HCl in ether (2.7 mL) and stirred at room temperature under an atmosphere of hydrogen for 24 h. The reaction mixture was filtered through celite and the filtrate evaporated in vacuo to give the title compound (0.59 g, 87%) as a pale yellow solid.

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe filtrate evaporated in vacuo

出典と根拠

ORDレコード
ord-aab42d12505d4aff9039aae1fb862f60
出典データセット
uspto-grants-2005_09
特許番号
US06939871B2

関連ノート

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