Hydrochloric Acid → 6-(4-Piperidinyl)-4H-benzo[1,4]oxazin-3-one
反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:15][CH2:14][C:13](=[O:16])[NH:12][C:11]=3[CH:17]=2)=[CH:3][CH:2]=1.Cl>CO.CCOCC.[Pt](=O)=O>[NH:1]1[CH2:2][CH2:3][CH:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:15][CH2:14][C:13](=[O:16])[NH:12][C:11]=3[CH:17]=2)[CH2:5][CH2:6]1参加物
6
実験手順
A solution of 6-(4-pyridyl)-4H-benzo[1,4]oxazin-3-one (0.57 g, 2.52 mmol), in methanol (15 mL) was treated with platinum (IV) oxide (50 mg, 0.22 mmol) and 1M HCl in ether (2.7 mL) and stirred at room temperature under an atmosphere of hydrogen for 24 h. The reaction mixture was filtered through celite and the filtrate evaporated in vacuo to give the title compound (0.59 g, 87%) as a pale yellow solid.
後処理
- filtrationThe reaction mixture was filtered through celite
- customthe filtrate evaporated in vacuo
出典と根拠
- ORDレコード
- ord-aab42d12505d4aff9039aae1fb862f60
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06939871B2
反応ノート
読み込み中…