HCID 22326644、化合物 → 5-Quinolinol, 6-fluoro-2-methyl-

HRID 495440ノート

反応式

HRID 495440 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([F:14])[C:8]=2[O:12]C)[N:3]=1>Br>[F:14][C:7]1[C:8]([OH:12])=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([CH3:1])[CH:11]=[CH:10]2

参加物

3

反応物 1

HCID 22326644HCID 22326644、化合物

生成物 1

HCID 1355530195-Quinolinol, 6-fluoro-2-methyl-収率 73%

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

実験手順

A mixture of 2-methyl-5-methoxy-6-fluoroquinoline (2.07 g, 10.8 mmol) and 48% hydrobromic acid (30 ml) was stirred at reflux for 24 h. The reaction mix was reduced to minimum volume in vacuo and partitioned between dichloromethane (50 ml) and sat. aqueous sodium bicarbonate solution (50 ml). The organic layer was dried over sodium sulfate, filtered and evaporated in vacuo to give the title compound as a brown solid (1.39 g, 73%).

後処理

  1. temperatureat reflux for 24 h
  2. additionThe reaction mix
  3. custompartitioned between dichloromethane (50 ml) and sat. aqueous sodium bicarbonate solution (50 ml)
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-cc1d97f25d5041eab976e0344acd29d2
出典データセット
uspto-grants-2005_09
特許番号
US06939871B2

反応ノート

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