1-[3-(4-Nitrophenoxy)propyl]piperidine → 4-[3-(1-Piperidinyl)propoxy]aniline

HRID 495450ノート

反応式

HRID 495450 の反応式
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([O:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1)([O-])=O>CCO.[Pd]>[N:12]1([CH2:11][CH2:10][CH2:9][O:8][C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:19][CH:18]=2)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1

参加物

4

反応物 1

HCID 20579281-[3-(4-Nitrophenoxy)propyl]piperidine

生成物 1

HCID 219749324-[3-(1-Piperidinyl)propoxy]aniline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 1-[3-(4-nitro-phenoxy)-propyl]-piperidine (15.5 g, 58.6 mmol) and 10% Pd/C (12.5 g) in 150 mL of EtOH was placed under a balloon of H2. The mixture was stirred for 18 h. The catalyst was removed by suction filtration and the organics concentrated to give 4-(3-piperidin-1-yl-propoxy)-phenylamine as a yellowish oil.

後処理

  1. customThe catalyst was removed by suction filtration
  2. concentrationthe organics concentrated

出典と根拠

ORDレコード
ord-c29bf6dc048443bb98a3da09247fc448
出典データセット
uspto-grants-2005_09
特許番号
US06939874B2

反応ノート

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