Ethyl 4-chloro-7-methoxyquinoline-3-carboxylate → 7-Methoxy-3-ethoxycarbonylquinoline hydrochloride
反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([Cl:18])=[C:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:9]=[N:10]2)=[CH:5][CH:4]=1>CCO.[Pd]>[ClH:18].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:9]=[N:10]2)=[CH:5][CH:4]=1参加物
4
実験手順
To a stirred suspension of 7-methoxy-4-chloro-3-ethoxycarbonylquinoline (Step B, 1.53 g, 5 mmol) in EtOH (15 mL) under inert atmosphere was added Pd/C 10% (153 mg). The mixture was stirred at RT under H2 (atmospheric pressure) for 2 h. The mixture was filtered and solvent removed under vacuum to give crude 7-methoxy-3-ethoxycarbonylquinoline hydrochloride.
後処理
- filtrationThe mixture was filtered
- customsolvent removed under vacuum
出典と根拠
- ORDレコード
- ord-2b6b7ba4981e4432aba3692216a4cce2
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06939874B2
反応ノート
読み込み中…