Sodium Hydroxide → 7-Methoxyquinoline-3-carboxylic acid
反応式
Cl.[CH3:2][O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([C:14]([O:16]CC)=[O:15])[CH:10]=[N:11]2)=[CH:6][CH:5]=1.[OH-].[Na+]>CCO>[CH3:2][O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([C:14]([OH:16])=[O:15])[CH:10]=[N:11]2)=[CH:6][CH:5]=1参加物
4
実験手順
To a stirred solution of 7-methoxy-3-ethoxycarbonylquinoline hydrochloride (Step C, 1.45 g, 5.4 mmol) in EtOH (24 mL) was added at RT 2N NaOH (8 mL, 16 mmol). The reaction was stirred at RT overnight. After concentration under vacuum, the mixture was acidified with 1N HCl. The resulting solid was filtered off, washed with water and dried over P2O5 to give 7-methoxy-3-carboxyquinoline.
後処理
- concentrationAfter concentration under vacuum
- filtrationThe resulting solid was filtered off
- washwashed with water
- dry with materialdried over P2O5
出典と根拠
- ORDレコード
- ord-c39495bfa0a2429992f8d4b3cad26284
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06939874B2
反応ノート
読み込み中…