Thionyl Chloride → (2-Chloro-4-methoxyphenyl)acetyl chloride

HRID 495519ノート

反応式

HRID 495519 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:13])=O.S(Cl)([Cl:16])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([Cl:16])=[O:13]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 42091322-(2-Chloro-4-methoxyphenyl)acetic acid

生成物 1

HCID 22327520(2-Chloro-4-methoxyphenyl)acetyl chloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

160 g of 2-chloro-4-methoxyphenylacetic acid are suspended in 210 ml of toluene, and the suspension is stirred together with 96 ml of thionyl chloride at 80° C. until the evolution of gas has ceased. The volatile components are stripped off, and the residue is distilled. 90 g of an orange oil are obtained (thin-film evaporator 170° C., 0.08 mbar).

後処理

  1. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-24d808e8b3a94d99a0479958d73eed3d
出典データセット
uspto-grants-2005_09
特許番号
US06939888B2

反応ノート

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