Ethyl 2-chlorophenyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate → Ethyl 2-chlorophenyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate

HRID 495613ノート

反応式

HRID 495613 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([C:14]1[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][C:17]([N+:24]([O-])=O)=[CH:16][C:15]=1[N+:27]([O-])=O)[C:9](=[O:13])[O:10][CH2:11][CH3:12]>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([C:14]1[C:19]([C:20]([F:21])([F:23])[F:22])=[CH:18][C:17]([NH2:24])=[CH:16][C:15]=1[NH2:27])[C:9](=[O:13])[O:10][CH2:11][CH3:12]

参加物

4

反応物 1

HCID 20827737Ethyl 2-chlorophenyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate

生成物 1

HCID 20827736Ethyl 2-chlorophenyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

Ethyl 2-chlorophenyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate (0.645 g) was dissolved in ethyl acetate (100 ml), and to the solution was added 10% Pd—C (0.58 g). The reaction mixture was stirred under hydrogen atmosphere for 11 hours. The catalyst was filtered, and washed with ethyl acetate. The filtrate and washing were combined and concentrated in vacuo to give the title compound (0.543 g, 98%).

後処理

  1. filtrationThe catalyst was filtered
  2. washwashed with ethyl acetate
  3. washThe filtrate and washing
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-55614f05576d45bc80a182b2496dd400
出典データセット
uspto-grants-2005_09
特許番号
US06939887B2

反応ノート

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