Ethyl 4-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate → Ethyl 4-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate

HRID 495627

反応式

HRID 495627 の反応式
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]([C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][C:16]([N+:23]([O-])=O)=[CH:15][C:14]=2[N+:26]([O-])=O)[C:8](=[O:12])[O:9][CH2:10][CH3:11])=[CH:4][CH:3]=1>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]([C:13]2[C:18]([C:19]([F:22])([F:20])[F:21])=[CH:17][C:16]([NH2:23])=[CH:15][C:14]=2[NH2:26])[C:8](=[O:12])[O:9][CH2:10][CH3:11])=[CH:29][CH:30]=1

参加物

4

反応物 1

HCID 20827746Ethyl 4-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate

生成物 1

HCID 20827745Ethyl 4-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate収率 97.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

Ethyl 4-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate (294.7 mg) was dissolved in ethyl acetate (20 ml), and to the solution was added 10% Pd—C (267.7 mg). The reaction mixture was stirred under hydrogen atmosphere for 7 hours. The catalyst was filtered, and washed with ethyl acetate. The filtrate was concentrated in vacuo to give the title compound (248.7 mg).

後処理

  1. filtrationThe catalyst was filtered
  2. washwashed with ethyl acetate
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-22e9506486f448879edec20695904024
出典データセット
uspto-grants-2005_09
特許番号
US06939887B2

関連ノート

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