Hydrochloric Acid → HCID 22327356、化合物

反応式

[NH2:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[C:3]=1[N:13]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=1)[C:14](=O)[O:15]CC.[H-].[Na+].Cl>C(O)C>[Br:8][C:6]1[CH:5]=[C:4]([C:9]([F:12])([F:10])[F:11])[C:3]2[N:13]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:29])[F:27])[CH:21]=3)[C:14](=[O:15])[NH:1][C:2]=2[CH:7]=1

参加物

実験手順

To a solution of ethyl 2-amino-4-bromo-6-(trifluoromethyl)phenyl[3-(trifluoromethyl)benzyl]carbamate (257.8 mg) in ethanol (10 ml) was added sodium hydride (60%) (48.7 mg). The reaction mixture was heated at reflux for 1.5 hours. To the reaction mixture was added 1N hydrochloric acid, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title compound (247.7 mg, quantitative yield).