Acetic Acid → 2-Acetoxy-3-bromo-tetrahydropyran

HRID 49579ノート

反応式

HRID 49579 の反応式
C1C(=O)N([Br:8])C(=O)C1.[O:9]1[CH:14]=[CH:13][CH2:12][CH2:11][CH2:10]1.[C:15]([OH:18])(=[O:17])[CH3:16]>C(OCC)C>[C:15]([O:18][CH:14]1[CH:13]([Br:8])[CH2:12][CH2:11][CH2:10][O:9]1)(=[O:17])[CH3:16]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 80803,4-dihydro-2H-pyranHCID 67184N-bromobutanimide

生成物 1

HCID 122985732-Acetoxy-3-bromo-tetrahydropyran収率 73%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To the solution of N-bromosuccimide (4.5 g ) in acetic acid (14.5 ml), was added dropwise 2.3 ml of 3,4-dihydro-2H-pyran at 10° C. The reaction mixture was diluted with 50 ml of diethyl ether and washed with 50 ml of water three times. The organic layer was washed with 1N NaHCO3 solution, dried, and then concentrated under a reduced pressure to give 4.1 g of 2-acetoxy-3-bromo-tetrahydropyran as a colorless oil (yield: 73%).

後処理

  1. washwashed with 50 ml of water three times
  2. washThe organic layer was washed with 1N NaHCO3 solution
  3. customdried
  4. concentrationconcentrated under a reduced pressure

出典と根拠

ORDレコード
ord-e8b7fdd7e15b4edca43e03658d05f9d4
出典データセット
uspto-grants-2004_03
特許番号
US06706888B2

反応ノート

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