Ethyl diazoacetate → Ethyl 2-(benzyloxymethyl)cyclopropanecarboxylate

HRID 496051

反応式

HRID 496051 の反応式
[N+](=[CH:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])=[N-].[CH2:9]([O:16][CH2:17][CH:18]=[CH2:19])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CCOCC>[CH2:9]([O:16][CH2:17][CH:18]1[CH2:19][CH:3]1[C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 12192Ethyl diazoacetate2 回HCID 84542Allyl benzyl ether

生成物 1

HCID 22325150Ethyl 2-(benzyloxymethyl)cyclopropanecarboxylate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

31.2 g of ethyl diazoacetate are added to a solution of 0.3 mol of allyl benzyl ether in 150 ml of ether with the aid of a push-syringe. After stirring for 16 hours, 31.2 g of ethyl diazoacetate are added again. After 24 hours the mixture is filtered. The organic phase is washed with saturated NaHCO3 solution and then treated in customary manner. Chromatography over silica gel (dichloromethane) allows the expected product to be obtained.

後処理

  1. filtrationAfter 24 hours the mixture is filtered
  2. washThe organic phase is washed with saturated NaHCO3 solution
  3. additiontreated in customary manner
  4. customto be obtained

出典と根拠

ORDレコード
ord-c809cba580fc45cd9cee4bfaa41681aa
出典データセット
uspto-grants-2005_09
特許番号
US06943184B2

関連ノート

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