Sodium Hydroxide → 1-(Methoxycarbonyl)cyclopropane-1-carboxylic acid

HRID 496054ノート

反応式

HRID 496054 の反応式
[OH-].[Na+].[C:3]1([C:10]([O-:12])=[O:11])([C:6]([O:8][CH3:9])=[O:7])[CH2:5][CH2:4]1>CO>[CH3:9][O:8][C:6]([C:3]1([C:10]([OH:12])=[O:11])[CH2:5][CH2:4]1)=[O:7]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 22325078Monomethyl cyclopropane-1,1-dicarboxylate

生成物 1

HCID 138618231-(Methoxycarbonyl)cyclopropane-1-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1.45 liters of 1N sodium hydroxide solution are added to a solution, cooled to 5° C., of 1.45 ml of methyl 1,1-cyclopropanedicarboxylate in 2.5 liters of methanol. After stirring for 4 days at ambient temperature, the mixture is three-quarters concentrated, extracted with ether and then treated in customary manner, allowing the expected product to be isolated.

後処理

  1. concentrationconcentrated
  2. extractionextracted with ether
  3. additiontreated in customary manner
  4. customto be isolated

出典と根拠

ORDレコード
ord-4a70eccecef643dd8b83003fe0b11ca1
出典データセット
uspto-grants-2005_09
特許番号
US06943184B2

反応ノート

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