Potassium Iodide → 1-(Dimethylamino)cyclopropaneacetonitrile
反応式
Cl.Cl[CH2:3][C:4]1([N:7]([CH3:9])[CH3:8])[CH2:6][CH2:5]1.[C-:10]#[N:11].[Na+].[I-].[K+].C(=O)([O-])[O-].[Na+].[Na+].[Cl-].[Na+]>CS(C)=O>[CH3:8][N:7]([CH3:9])[C:4]1([CH2:3][C:10]#[N:11])[CH2:6][CH2:5]1参加物
7
実験手順
30.3 g of the compound obtained in Step 1 are added to a solution of 43 g of sodium cyanide and 3.5 g of potassium iodide in 400 ml of dimethyl sulphoxide. After stirring for 20 hours at ambient temperature, 490 ml of 10% aqueous sodium carbonate solution and then sodium chloride are added. The mixture is extracted with ether. After conventional treatment of the organic phases, chromatography over silica gel allows the expected product to be isolated.
後処理
- extractionThe mixture is extracted with ether
- customto be isolated
出典と根拠
- ORDレコード
- ord-21e5b1bc66e0456e9622a0f123b7d193
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06943184B2
反応ノート
読み込み中…