ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Hydrochloric Acid → alpha-Methyl-3(2-naphthoyl)benzene Acetic Acid

HRID 49642
ノート
印刷プレビュー

反応式

HRID 49642 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([C:13]1[CH2:14][CH2:15][CH2:16][C:17]2[C:21]=1[O:20][C:19](=[O:22])[C:18]=2[CH3:23])=[O:12].[K+].C([O-])(=O)C.C1(C)C=CC=CC=1.Cl>O>[CH3:23][CH:18]([C:17]1[CH:16]=[CH:15][CH:14]=[C:13]([C:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)=[O:12])[CH:21]=1)[C:19]([OH:22])=[O:20]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 517044Potassium AcetateHCID 129913627-(2-naphthoyl)-3-methyl-5,6-dihydro-2(4H)-benzofuranone

生成物 1

HCID 9901064alpha-Methyl-3(2-naphthoyl)benzene Acetic Acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
220 °C

実験手順

A mixture of 7-(2-naphthoyl)-3-methyl-5,6-dihydro-2(4H)-benzofuranone (10 g) and acetic acid potassium salt (0.3 g) was added to a reactor and stirred for 1 hr at 220° C. The reaction mixture was cooled down to room temperature. Toluene and water were added to the reaction mixture and acidified to pH 2 with 5% hydrochloric acid. Toluene layer separated was dried over anhydrous MgSO4, filtered and evaporated to give crude product. The crude product was purified by column chromatograph on silica gel by eluting with a mixture of ethylacetate and n-hexane (1:5) to give the desired product (9:42 g, 94 % .

後処理

  1. additionwas added to a reactor
  2. temperatureThe reaction mixture was cooled down to room temperature
  3. customToluene layer separated
  4. dry with materialwas dried over anhydrous MgSO4
  5. filtrationfiltered
  6. customevaporated
  7. customto give crude product
  8. customThe crude product was purified by column chromatograph on silica gel
  9. washby eluting with a mixture of ethylacetate and n-hexane (1:5)

出典と根拠

ORDレコード
ord-1f4befc33ffa492db518647e07a976d7
出典データセット
uspto-grants-2004_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06706917B1

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート