HCID 22321559、化合物 → 4-(chloromethyl)-1-methyl-1H-1,2,3-triazole hydrochloride
反応式
O.[ClH:2].[CH3:3][N:4]1[CH:8]=[C:7]([CH2:9]O)[N:6]=[N:5]1>S(Cl)(Cl)=O>[ClH:2].[Cl:2][CH2:9][C:7]1[N:6]=[N:5][N:4]([CH3:3])[CH:8]=1参加物
3
実験手順
1-Methyl-4-hydroxymethyl-1,2,3-triazole hydrochloride hydrate (1.0 g, 6.08 mmol) was suspended in 20 ml thionyl chloride and the mixture was refluxed for 1 hour. Excess thionyl chloride was evaporated off and the residue was triturated with diethyl ether (25 ml). The white solid produced was washed by decantation with diethyl ether and dried in vacuo to give the required product (0.52 g, 51%). 1H NMR (360 MHz, d6-DMSO) 4.04 (3H, s), 4.82 (2H, s), 8.16 (1H, s); MS+131&133.
後処理
- temperaturethe mixture was refluxed for 1 hour
- customExcess thionyl chloride was evaporated off
- customthe residue was triturated with diethyl ether (25 ml)
- customThe white solid produced
- washwas washed by decantation with diethyl ether
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-5e76d283ec8042c99a665206f2ec6185
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06946461B2
反応ノート
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