Sodium hydride → ethyl-4-[(4-methoxybenzenesulfonyl)pyridin-3-ylmethylamino]-1-phenyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

HRID 496591

反応式

HRID 496591 の反応式
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=[C:15]([CH3:16])[C:3]=12.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([S:31]([NH:34][CH2:35][C:36]2[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=2)(=[O:33])=[O:32])=[CH:27][CH:26]=1.[H-].[Na+]>>[CH2:11]([O:10][C:8]([C:7]1[C:2]([N:34]([S:31]([C:28]2[CH:29]=[CH:30][C:25]([O:24][CH3:23])=[CH:26][CH:27]=2)(=[O:33])=[O:32])[CH2:35][C:36]2[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=2)=[C:3]2[C:15]([CH3:16])=[N:14][N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:4]2=[N:5][CH:6]=1)=[O:9])[CH3:12]

参加物

4

反応物 3

HCID 24758Sodium hydrideHCID 8097404-methoxy-N-(pyridin-3-ylmethyl)benzenesulfonamideHCID 11771453Ethyl 4-chloro-1-phenyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

生成物 1

HCID 22322150ethyl-4-[(4-methoxybenzenesulfonyl)pyridin-3-ylmethylamino]-1-phenyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

実験手順

Following the procedure of Example 38, the product of Example 43 is reacted with (4-methoxybenzenesulfonyl)(3-pyridinylmethyl) amine and sodium hydride to provide ethyl-4-[(4-methoxybenzenesulfonyl)pyridin-3-ylmethylamino]-1-phenyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate. m.p. 148°-150° C.

出典と根拠

ORDレコード
ord-bb60f5ac44674b9f947895277d617135
出典データセット
uspto-grants-2005_09
特許番号
US06946473B2

関連ノート

読み込み中…