Water → 2-Bromo-3-cyclohexyloxy pyridine
反応式
[H-].[Na+].[Br:3][C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[CH:6][N:5]=1.Br[CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.O>CN(C)C=O>[Br:3][C:4]1[C:9]([O:10][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:8][CH:7]=[CH:6][N:5]=1参加物
6
実験手順
Sodium hydride (160 mg) was dissolved in dimethylformamide (5 ml) and 2-bromo-3-pyridinol (500 mg) dissolved in dimethylformamide is slowly added dropwise. Then, bromocyclohexane (0.7 ml) was added to the solution and reacted for 5 hours at room temperature. Water was added to the suspension to dilute and extracted with ethyl acetate to separate an organic layer. The separated organic layer was dried with anhydrous magnesium sulfate and distilled under reduced pressure. As a result, 2-bromo-3-cyclohexyloxy pyridine (220 mg, yield: 30%) was obtained as an oil phase.
後処理
- additionis slowly added dropwise
- customreacted for 5 hours at room temperature
- additionto dilute
- extractionextracted with ethyl acetate
- customto separate an organic layer
- dry with materialThe separated organic layer was dried with anhydrous magnesium sulfate
- distillationdistilled under reduced pressure
出典と根拠
- ORDレコード
- ord-048d469ce30545f59c35fb3fe46cfc7d
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06946558B2
反応ノート
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