Tetrabutylammonium Fluoride → (5S)-5-(Hydroxymethyl)-1-methyl-2-pyrrolidinone
反応式
[N+](CCCC)(CCCC)(CCCC)CCCC.[F-].[Si]([O:26][CH2:27][C@H:28]1[N:32]([CH3:33])[C:31](=[O:34])[CH2:30][CH2:29]1)(C(C)(C)C)(C)C>C1COCC1>[OH:26][CH2:27][C@H:28]1[N:32]([CH3:33])[C:31](=[O:34])[CH2:30][CH2:29]1参加物
4
実験手順
Bu4NF (1 mol THF solution, 17.5 ml, 17.5 mmols) was added to a THF (100 ml) solution of the (5S)-5-[(tert-butyldimethylsilyloxy)methyl]-1-methylpyrrolidin-2-one (3.84 g, 15.8 mmols), and the mixture was stirred for 15 hours at room temperature. The reaction mixture was concentrated under reduced pressure, and then the residue was subjected to silica gel column chromatography (SiO2 150 g, MeOH—CHCl3 1:9 v/v) to obtain (5S)-5-(hydroxymethyl)-1-methylpyrrolidin-2-one as a mixture (2.46 g) with inseparable impurities.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-b498f257915f4d9c97597204d92e3915
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06949553B2
反応ノート
読み込み中…