Lithium Hydroxide → HCID 18188087、化合物

HRID 49708ノート

反応式

HRID 49708 の反応式
C([O:4][C:5]1[CH:6]=[C:7]([CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:8]=[C:9]([CH3:14])[C:10]=1[N+:11]([O-:13])=[O:12])(=O)C.[OH-].[Li+].C(OCC)(=O)C.[Cl-].[Na+]>CO.O>[OH:4][C:5]1[CH:6]=[C:7]([CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:8]=[C:9]([CH3:14])[C:10]=1[N+:11]([O-:13])=[O:12]

参加物

7

反応物 4

HCID 3939Lithium HydroxideHCID 5234Sodium ChlorideHCID 8857Ethyl AcetateHCID 18188096t-Butyl 3-acetoxy-5-methyl-4-nitrophenylacetate

生成物 1

HCID 18188087HCID 18188087、化合物収率 104.2%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of t-butyl 3-acetoxy-5-methyl-4-nitrophenylacetate (0.5 g, Reference Example 12) in methanol (6 mL) was treated with lithium hydroxide (0.2 g) in water (1.5 mL). After stirring for 2 hours the mixture was carefully acidified to pH 5 and then treated with ethyl acetate and sodium chloride. The organic layer was evaporated and the residue was dissolved in dichloromethane. This solution was dried and then evaporated to give the title compound (0.45 g) as a yellow green oil.

後処理

  1. customThe organic layer was evaporated
  2. dissolutionthe residue was dissolved in dichloromethane
  3. customThis solution was dried
  4. customevaporated

出典と根拠

ORDレコード
ord-3ba4b2586bbf420ba816ed6edb0e882f
出典データセット
uspto-grants-2004_03
特許番号
US06706738B2

反応ノート

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