N,N-Dimethylaniline → 7-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine

HRID 497725

反応式

HRID 497725 の反応式
[NH2:1][C:2]1[S:3][C:4]2[C:9](=O)[N:8]=[C:7]([S:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=3[F:20])[NH:6][C:5]=2[N:21]=1.P(Cl)(Cl)([Cl:24])=O.CN(C)C1C=CC=CC=1>CO.ClCCl>[Cl:24][C:9]1[C:4]2[S:3][C:2]([NH2:1])=[N:21][C:5]=2[N:6]=[C:7]([S:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=2[F:20])[N:8]=1

参加物

5

反応物 3

HCID 949N,N-DimethylanilineHCID 24813Phosphorus oxychlorideHCID 178508256HCID 178508256、化合物

生成物 1

HCID 112216507-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

The product from example 1, step (a) (0.89 g), phosphorus oxychloride (12 ml) and N,N-dimethylaniline (1.2 ml) were heated at reflux for 2 hours. The cooled reaction mixture was poured onto ice water and stirred for 2 hours. Chromatography (SiO2, methanol/dichloromethane as eluant) gave the subtitled compound.

後処理

  1. temperatureat reflux for 2 hours
  2. customThe cooled reaction mixture
  3. additionwas poured onto ice water

出典と根拠

ORDレコード
ord-02e158189ca04e1f92f16acf9bf29cee
出典データセット
uspto-grants-2005_09
特許番号
US06949643B2

関連ノート

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