化工社化工社 化学情報印刷レポート · 研究参考用
Water → 4-(4-Fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 4-(Trifluoromethoxy)benzoyl Chloride | HCID 142110 | — |
| 反応物 | 4-fluoro-N-(piperidin-4-yl)benzamide | HCID 4778226 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(4-Fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine | HCID 9822813 | — |
反応手順
To a solution of 4-(4-fluorobenzoylamino)piperidine (0.15 g) in dichloromethane (5 ml) were added in turn pyridine (82 μl) and 4-trifluoromethoxybenzoyl chloride (106 μ) at 0° C. The mixture was allowed to warm to ambient temperature and stirred for 4 hours, which was taken up into a mixture of water and dichloromethane. The separated organic layer was washed in turn with hydrochloric acid (1N), aqueous sodium hydrogen carbonate, and brine, and dried over magnesium sulfate. Evaporation of the solvent under reduced pressure gave 4-(4-fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine (205 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710043B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-12dc8b3889c647648bf71c64dcb75b6c |
| 出典メモ | uspto-grants-2004_03 |