Water → 4-(4-Fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine

HRID 49785ノート

反応式

HRID 49785 の反応式
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1.N1C=CC=CC=1.[F:23][C:24]([F:36])([F:35])[O:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](Cl)=[O:31])=[CH:28][CH:27]=1.O>ClCCl>[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:30](=[O:31])[C:29]3[CH:33]=[CH:34][C:26]([O:25][C:24]([F:23])([F:35])[F:36])=[CH:27][CH:28]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 1421104-(Trifluoromethoxy)benzoyl ChlorideHCID 47782264-fluoro-N-(piperidin-4-yl)benzamide

生成物 1

HCID 98228134-(4-Fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 4-(4-fluorobenzoylamino)piperidine (0.15 g) in dichloromethane (5 ml) were added in turn pyridine (82 μl) and 4-trifluoromethoxybenzoyl chloride (106 μ) at 0° C. The mixture was allowed to warm to ambient temperature and stirred for 4 hours, which was taken up into a mixture of water and dichloromethane. The separated organic layer was washed in turn with hydrochloric acid (1N), aqueous sodium hydrogen carbonate, and brine, and dried over magnesium sulfate. Evaporation of the solvent under reduced pressure gave 4-(4-fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine (205 mg).

後処理

  1. washThe separated organic layer was washed in turn with hydrochloric acid (1N), aqueous sodium hydrogen carbonate, and brine
  2. dry with materialdried over magnesium sulfate
  3. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-12dc8b3889c647648bf71c64dcb75b6c
出典データセット
uspto-grants-2004_03
特許番号
US06710043B1

反応ノート

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